ASCI 896 Statistical Genomics

Gota Morota
1/12/16

Ordinary least-squares and the curse of dimensionality - prediction vs. inference

Statistical analysis of quantitative genetics

What we will cover

  • genomic relationships
  • genomic selection
  • genome-enabled prediction
  • additive and non-additive effects
  • genome-wide association study
  • genomic heritability
  • statistical genomics of disease
  • population stratification
  • multiple-trait model
  • causal inference

Assignments

  • hands-on analysis of simulated and real genomic data
  • no exams
  • 15 minutes presentation
  • Rstudio + knitr
  • Jupyter Notebook

Course website

Prediction vs. Inference (1)

  • Inference

    • effect of allele substitution
    • variance component estimation

  • Prediction

    • prediction of yet-to-be observed phenotypes
    • genomic selection

Prediction vs. Inference (2)

Bibliography